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You are an SLO (Service Level Objective) expert specializing in implementing reliability standards and error budget-based practices. Design SLO frameworks, define SLIs, and build monitoring that balances reliability with delivery velocity.

Deep generative models for single-cell omics. Use when you need probabilistic batch correction (scVI), transfer learning, differential expression with uncertainty, or multi-modal integration (TOTALVI, MultiVI). Best for advanced modeling, batch effects, multimodal data. For standard analysis pipelines use scanpy.

Annotate CLIP-seq binding sites to genomic features including 3'UTR, 5'UTR, CDS, introns, and ncRNAs. Use when characterizing where an RBP binds in transcripts.

Validate that input meets prerequisites based on the user's saved standards for the project type. Use at the start of any quality pipeline to ensure the user has provided sufficient requirements.

Implemente comunicação orientada a eventos usando BlueprintEventBus para coordenação entre módulos. Esta skill permite que módulos se comuniquem sem acoplamento forte, transmitindo eventos de domínio e implementando fluxos de trabalho orientados a eventos, garantindo que os eventos sigam convenções de nomenclatura como [módulo].[ação].

Gerenciador de Contas para Agentes de Codificação, permitindo troca de contas em menos de 100ms para CLIs de codificação de IA com assinaturas de custo fixo.

O SDK de Tradução de Documentos do Azure AI permite a tradução em lote de documentos com preservação de formato. Ele é usado para traduzir Word, PDF, Excel, PowerPoint e outros formatos em escala.

Workflow from differential expression results to functional enrichment analysis. Covers GO, KEGG, Reactome enrichment with clusterProfiler and visualization. Use when taking DE results to pathway enrichment.

Post-ship documentation update. Reads all project docs, cross-references the diff, updates README/ARCHITECTURE/CONTRIBUTING/CLAUDE.md to match what shipped, polishes CHANGELOG voice, cleans up TODOS, and optionally bumps VERSION. Use when asked to "update the docs", "sync documentation", or "post-ship docs". Proactively suggest after a PR is merged or code is shipped. (gstack)

AI video generation skill with auto model selection across Seedance 2, Kling 3.0, HappyHorse, and 10+ models. Produces finished multi-shot videos (5–120s) from text, images, URLs, scripts, or audio — including AI music, lip sync, and multi-shot sequencing. No prompts to write, no models to choose. USE FOR: video production, AI video, make a video, product video, brand video, promotional clip, expl

End-to-end post-GWAS causal inference pipeline orchestrating heritability partitioning, genetic correlation, Mendelian randomization with CHP-aware sensitivity (CAUSE / LHC-MR), colocalization, fine-mapping with SuSiE / FOCUS, mediation, TWAS triangulation, cis-pQTL drug-target MR, effector-gene prioritization (L2G / PoPS / cS2G), and GenomicSEM common-factor GWAS. Use when triangulating causal in

Analyzes cfDNA fragment size distributions and fragmentomics features using FinaleToolkit or Griffin. Extracts nucleosome positioning patterns, fragment ratios, and DELFI-style fragmentation profiles for cancer detection. Use when leveraging fragment patterns for tumor detection or tissue-of-origin analysis.