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Test smart contracts comprehensively using Hardhat and Foundry with unit tests, integration tests, and mainnet forking. Use when testing Solidity contracts, setting up blockchain test suites, or validating DeFi protocols.

Manual-only skill for minimizing total codebase size. Only activate when explicitly requested by user. Measures success by final code amount, not effort. Bias toward deletion.

Build high-performance async APIs with FastAPI, SQLAlchemy 2.0, and

分析家族病史、评估遗传风险、识别家庭健康模式、提供个性化预防建议

Decision framework for choosing between regex and LLM when parsing structured text — start with regex, add LLM only for low-confidence edge cases.

Create Mermaid diagrams in Obsidian including flowcharts, sequence diagrams, class diagrams, and more. Use when visualizing processes, system architectures, workflows, or any structured relationships in Obsidian notes.

Use when creating new Claude Code skills or improving existing ones - ensures skills are discoverable, scannable, and effective through proper structure, CSO optimization, and real examples

Generate alignment statistics using samtools flagstat, stats, depth, coverage, and mosdepth. Use when assessing alignment quality, calculating coverage, or generating QC reports.

Detects non-functional "theater" code that appears complete but doesn't actually work. Use this skill to identify code that looks correct in static analysis but fails during execution, preventing fake implementations from reaching production. Scans for suspicious patterns, validates actual functionality, and reports findings with recommendations.

Unified media generation via fal.ai MCP — image, video, and audio. Covers text-to-image (Nano Banana), text/image-to-video (Seedance, Kling, Veo 3), text-to-speech (CSM-1B), and video-to-audio (ThinkSound). Use when the user wants to generate images, videos, or audio with AI.

Process Hi-C read pairs using pairtools. Parse alignments, filter duplicates, classify pairs, and generate contact statistics from Hi-C sequencing data. Use when processing raw Hi-C read pairs.

Nest.js framework expert specializing in module architecture, dependency injection, middleware, guards, interceptors, testing with Jest/Supertest, TypeORM/Mongoose integration, and Passport.js authentication. Use PROACTIVELY for any Nest.js application issues including architecture decisions, testing strategies, performance optimization, or debugging complex dependency injection problems. If a spe