From DNA Variants to Protein Structure: AlphaFold2, AlphaFold3, RoseTTAFold
Decision Framework
- Prioritize variants from genomic models (splice/expression/regulatory)
- Keep coding or coding-adjacent candidates
- Map to protein regions (domain, interface, active-site proximity)
- Run structural follow-up; assess confidence
Non-coding variants (splice, regulatory) rarely benefit from structure modeling. Save structural prediction for missense variants where mechanism depends on prote
[Description truncada. Veja o README completo no GitHub.]