CITE-seq and Multiome Data Integration
ADT Normalization
ADT counts differ fundamentally from RNA: high background (~100-500 counts even in negative cells), no true zeros, bimodal distribution (negative + positive populations).
CLR (Centered Log-Ratio)
def clr_normalize(X):
"""X: cells x proteins matrix (raw counts).""
[Description truncada. Veja o README completo no GitHub.]