Genome-Wide Association Studies (GWAS)
Study Design
GWAS tests ~1–10M SNPs for association with a phenotype by comparing allele frequencies (binary traits) or correlating allele dosage with trait values (quantitative traits).
| Factor | Recommendation |
|---|---|
| Sample size | n > 5,000 for common variants; n > 50,000 for small effects |
| Confounders | Age, sex, ancestry, batch — include as covariates |
| Multiple testing | ~1M independent tests → threshold p < 5×10⁻⁸ |
**Why p < 5×1
[Description truncada. Veja o README completo no GitHub.]