bio-causal-genomics-proteome-mr-drug-target

Name: bio-causal-genomics-proteome-mr-drug-target
Rating: 5 (1 reviews)
Author: bg-szy

Runs cis-pQTL Mendelian randomization for drug-target validation using UKB-PPP (Olink), deCODE (SomaScan), Fenland, INTERVAL, ARIC, and FinnGen-PPP proteomes plus colocalization triangulation, phenome-wide on-target adverse-effect scans, cross-platform Olink/SomaScan replication, and PAV (protein-altering variant) sensitivity. Use when nominating or de-risking a drug target from plasma-proteome GW

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Updated 14 days ago

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Version Compatibility

Reference examples tested with: TwoSampleMR 0.5.11+, MendelianRandomization 0.10+, MR-PRESSO 1.0+, coloc 5.2.3+, susieR 0.12.35+, ieugwasr 1.0+, plink2 2.00a5+, R 4.4+.

Before using code patterns, verify installed versions match. If versions differ:

R: packageVersion('<pkg>') then ?function_name to verify parameters
CLI: plink2 --version; VEP vep --help

If code throws OAuth or rate-limit errors from OpenGWAS, or a missing dataset$N from coloc, introspect

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