SnpEff + SnpSift — Variant Annotation and Filtering

Overview

SnpEff annotates variants in VCF files by predicting their functional consequences: impact level (HIGH, MODERATE, LOW, MODIFIER), affected gene and transcript, amino acid change, and HGVS notation. SnpSift is the companion tool for filtering, sorting, and enriching annotated VCFs with external databases such as ClinVar and dbSNP. Together they form a fast, self-contained pipeline for going from raw variant calls to biologically

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