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Discover RBP binding motifs from CLIP-seq peaks or single-nucleotide crosslink sites using HOMER, MEME/STREME, kpLogo, mCross (CL-position-registered motifs), PEKA (positional k-mer enrichment), RBPamp (affinity), and RNA Bind-n-Seq (RBNS) cross-validation. Use when characterizing RBP sequence specificity, registering motifs to crosslink positions, validating in vivo CLIP motifs against in vitro R

PC and console game development principles. Engine selection, platform features, optimization strategies.

Generates comprehensive operational runbooks for any system or process. Reads codebase, infrastructure config, and deployment scripts to produce structured runbook.md files formatted for on-call engineers. Use when you need operations documentation, incident response guides, deployment procedures, or disaster recovery plans.

Parses and processes SARIF files from static analysis tools like CodeQL, Semgrep, or other scanners. Triggers on "parse sarif", "read scan results", "aggregate findings", "deduplicate alerts", or "process sarif output". Handles filtering, deduplication, format conversion, and CI/CD integration of SARIF data. Does NOT run scans — use the Semgrep or CodeQL skills for that.

RNA-seq specific quality control including rRNA contamination detection, strandedness verification, gene body coverage, and transcript integrity metrics. Use when validating RNA-seq libraries before differential expression analysis.

Reproduces the full prefill sensitivity analysis pipeline for reward hacking indicators. Use when evaluating how susceptible model checkpoints are to exploit-eliciting prefills, computing token-based trajectories, or comparing logprob vs token-count as predictors of exploitability.

Conducts effective daily standup meetings for agile teams, facilitating standups, tracking blockers, and improving team synchronization. It handles standup format, time management, and blocker resolution.

Predict patient response to immune checkpoint inhibitors (ICIs) using multi-biomarker integration. Given a cancer type, somatic mutations, and optional biomarkers (TMB, PD-L1, MSI status), performs systematic analysis across 11 phases covering TMB classification, neoantigen burden estimation, MSI/MMR assessment, PD-L1 evaluation, immune microenvironment profiling, mutation-based resistance/sensiti

Azure Identity SDK for Python authentication. Use for DefaultAzureCredential, managed identity, service principals, and token caching.

Review investment portfolios for risk, diversification, fees. Asset allocation recommendations, tax-loss harvesting, rebalancing.

Land and deploy workflow. Merges the PR, waits for CI and deploy, verifies production health via canary checks. Takes over after /ship creates the PR. Use when: "merge", "land", "deploy", "merge and verify", "land it", "ship it to production". (gstack)

Expert DevOps troubleshooter specializing in rapid incident