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Guide for implementing Grafana Loki - a horizontally scalable, highly available log aggregation system. Use when configuring Loki deployments, setting up storage backends (S3, Azure Blob, GCS), writing LogQL queries, configuring retention and compaction, deploying via Helm, integrating with OpenTelemetry, or troubleshooting Loki issues on Kubernetes.

Create and use BAI/CSI indices for BAM/CRAM files using samtools and pysam. Use when enabling random access to alignment files or fetching specific genomic regions.

Design multi-stage CI/CD pipelines with approval gates, security checks, and deployment orchestration. Use when architecting deployment workflows, setting up continuous delivery, or implementing GitOps practices.

An advanced intent interpretation system that analyzes user requests using cognitive science principles to extrapolate logical volition. It's used for ambiguous requests, to improve response quality through deeper understanding, or to help users clarify their true needs by applying probabilistic intent mapping, first principles decomposition, and Socratic clarification.

Score deal velocity based on email response times, meeting frequency, and stakeholder engagement. Predict which deals will close vs stall.

Calculates molecular fingerprints (ECFP/Morgan, FCFP, MACCS, RDKit, AtomPair, TopologicalTorsion, Avalon, MAP4, MHFP6) and physicochemical descriptors (Lipinski, QED, TPSA, Crippen LogP, 3D shape) with explicit choice tables, bit vs count semantics, and partial-charge model selection. Use when featurizing molecules for similarity, QSAR, virtual screening, or ML, or selecting the correct fingerprin

Automate PagerDuty tasks via Rube MCP (Composio): manage incidents, services, schedules, escalation policies, and on-call rotations. Always search tools first for current schemas.

Performs 3D shape-based similarity searching using ROCS (OpenEye), USRCAT (ultra-fast), Open3DAlign (RDKit), ESPSim (electrostatic), and ShaEP with explicit handling of Tanimoto-Combo (shape + color), shape vs ECFP4 complementarity, conformer-ensemble searching, alignment optimization, and scaffold hopping. Use when searching for shape-mimicking compounds with different scaffolds, identifying bioi

Master software architect specializing in modern architecture.

Run a multi-perspective Mind Council deliberation on any question, decision, or creative challenge. Use this skill whenever the user wants diverse viewpoints, needs help making a tough decision, asks for a council/panel/board discussion, wants to explore a problem from multiple angles, requests devil's advocate analysis, or says things like "what would different experts think about this", "help me

Force verification before answering questions involving versions, dates, status, or "current" state. Prevents hallucinations at the REASONING level by checking assertions.yaml and WebSearch before forming beliefs. Triggers on software versions, release status, dates, and package versions.

Symbolic math in Python: exact algebra, calculus (derivatives, integrals, limits), equation solving, symbolic matrices, ODEs, code gen (lambdify, C/Fortran). Use for exact symbolic results. For numerical use numpy/scipy; for stats use statsmodels.