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Resolve the architecture of focal oncogene amplifications — extrachromosomal DNA (ecDNA), breakage-fusion-bridge (BFB) cycles, homogeneously staining regions (HSR), and linear amplification — from whole-genome sequencing with AmpliconArchitect, the AmpliconSuite pipeline, and AmpliconClassifier. Covers copy-number seed selection, breakpoint-graph reconstruction, balanced-flow optimization, ecDNA c

When the user wants to create or optimize in-app paywalls, upgrade screens, upsell modals, or feature gates. Also use when the user mentions "paywall," "upgrade screen," "upgrade modal," "upsell," "feature gate," "convert free to paid," "freemium conversion," "trial expiration screen," "limit reached screen," "plan upgrade prompt," or "in-app pricing." Distinct from public pricing pages (see page-

Guide for implementing Grafana Loki - a horizontally scalable, highly available log aggregation system. Use when configuring Loki deployments, setting up storage backends (S3, Azure Blob, GCS), writing LogQL queries, configuring retention and compaction, deploying via Helm, integrating with OpenTelemetry, or troubleshooting Loki issues on Kubernetes.

Create and use BAI/CSI indices for BAM/CRAM files using samtools and pysam. Use when enabling random access to alignment files or fetching specific genomic regions.

Calculates molecular fingerprints (ECFP/Morgan, FCFP, MACCS, RDKit, AtomPair, TopologicalTorsion, Avalon, MAP4, MHFP6) and physicochemical descriptors (Lipinski, QED, TPSA, Crippen LogP, 3D shape) with explicit choice tables, bit vs count semantics, and partial-charge model selection. Use when featurizing molecules for similarity, QSAR, virtual screening, or ML, or selecting the correct fingerprin

Performs 3D shape-based similarity searching using ROCS (OpenEye), USRCAT (ultra-fast), Open3DAlign (RDKit), ESPSim (electrostatic), and ShaEP with explicit handling of Tanimoto-Combo (shape + color), shape vs ECFP4 complementarity, conformer-ensemble searching, alignment optimization, and scaffold hopping. Use when searching for shape-mimicking compounds with different scaffolds, identifying bioi

Master software architect specializing in modern architecture.

Run a multi-perspective Mind Council deliberation on any question, decision, or creative challenge. Use this skill whenever the user wants diverse viewpoints, needs help making a tough decision, asks for a council/panel/board discussion, wants to explore a problem from multiple angles, requests devil's advocate analysis, or says things like "what would different experts think about this", "help me

Analyze genome collinearity and syntenic blocks using MCScanX, SyRI, and JCVI for comparative genomics. Detect conserved gene order, chromosomal rearrangements, and whole-genome duplications. Use when comparing genome structure between species or identifying conserved genomic regions.

Expert startup business analyst specializing in market sizing.

Expert guidance for Google Kubernetes Engine (GKE) operations, covering cluster management, workload deployment, scaling, monitoring, troubleshooting, and optimization. Use this for GKE clusters, Kubernetes on GCP, container orchestration, or assistance with kubectl, GKE networking, autoscaling, workload identity, and GKE features like Autopilot.

Comprehensive GitOps methodology and principles skill for cloud-native operations. Use when (1) Designing GitOps architecture for Kubernetes deployments, (2) Implementing declarative infrastructure with Git as single source of truth, (3) Setting up continuous deployment pipelines with ArgoCD/Flux/Kargo, (4) Establishing branching strategies and repository structures, (5) Troubleshooting drift, syn