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Prefer static import over dynamic import() in TypeScript/JavaScript. Use when writing or reviewing import statements.

Do not use non-null assertion operator (!) in TypeScript. Use optional chaining, type guards, or nullish checks instead. Use when writing or reviewing TypeScript code.

Python arithmetic, comparison, logical, and membership operators with bioinformatics applications, including codon frames, GC content, and quality filters.

PWM/PFM/PPM construction, scoring, scanning, information content, sequence logos, and PROSITE pattern conversion.

Explores sequence motifs and protein domains, covering PWM construction and scanning, information content, sequence logos, PROSITE patterns, and Pfam/HMMER concepts.

Reference checklist for Basic Memory note quality — rules preventing self-referential content in subject-domain notes (the fourth-wall anti-pattern). Preloaded into knowledge-maintainer and knowledge-gardener agents via the skills frontmatter field.

Technical documentation writing skill covering API docs, architecture documentation, deployment guides, and various technical writing best practices. Use this skill when creating technical documentation, writing API documentation, creating architecture design documents, or need templates for deployment and operations manuals.

Use when defining severity levels and on-call procedures, when creating a runbook for a critical service, when an incident is actively happening and a structured response is needed, or when writing a blameless postmortem after Sev1 or Sev2 resolution.

Use when the user wants to "model a problem", "translate to math", "formalize a problem", "mathematical modeling", "how to model this", "set up the math", "define the problem", "what kind of problem is this", or discusses translating real-world problems into formal mathematical structures. Covers any computational domain — discrete, continuous, statistical, or hybrid.

This skill pairs a Claude Code session with an OpenAI Codex CLI session for seamless communication, eliminating the need for copy-paste. It establishes a background listener and file-based message passing, providing Claude with send/recv/ask primitives.

Use this skill at the end of any phase that changed SDLC artifacts to update the SDLC documentation tree — the artifact index, requirements traceability matrix, architecture manifest, changelog, and any user-facing docs affected by the change. Also trigger when the user says "update docs", "refresh the index", "regenerate the traceability matrix", or after a deployment completes.

Analyzes any website page against Google's official AI Optimization Guide, debunked myths, and broader AI search landscape standards (Perplexity, ChatGPT, Gemini, Copilot). Use this skill to audit a page URL or content for AI search visibility.