Explore skills

Create the deliverable (code, documentation, tests, content) following the user's standards and best practices. Use after validation passes to actually build the work product.

Detect somatic and germline copy number variants from targeted, exome, and whole-genome sequencing with CNVkit, a read-depth caller that combines on-target and off-target (antitarget) coverage. Covers panel-of-normals construction, flat-reference tumor-only calling, hybrid/amplicon/WGS modes, CBS vs HMM segmentation selection, purity-aware integer calling, and reconciliation against GATK and allel

Filter and select sequences by criteria (length, ID, GC content, patterns) using Biopython. Use when subsetting sequences, removing unwanted records, or selecting by specific criteria.

Detect and quantify translated ORFs from Ribo-seq data including uORFs and novel ORFs using RiboCode and ORFquant. Use when identifying translated regions beyond annotated coding sequences or quantifying ORF-level translation.

Generate variant statistics, sample concordance, and quality metrics using bcftools stats and gtcheck. Use when evaluating variant quality, comparing samples, or summarizing VCF contents.

Generate variant statistics, sample concordance, and quality metrics using bcftools stats and gtcheck. Use when evaluating variant quality, comparing samples, or summarizing VCF contents.

Cache expensive file processing results using SHA-256 content hashes — path-independent, auto-invalidating, with service layer separation.

Enforce AP Style and newsroom conventions for journalism writing. Use when writing news articles, editing drafts, creating headlines, or converting notes into publishable copy. Ensures professional standards for attribution, numbers, dates, and formatting.

Computer vision for bio-image preprocessing, feature detection, real-time microscopy. Color conversion, morphology, contour/blob detection, template matching, optical flow on fluorescence/brightfield. 10-100× faster than pure Python via C++. Use scikit-image for scientific morphometry/regionprops; OpenCV for real-time, video, classical feature extraction.

Look up library documentation using Context7. Use when needing API reference, library docs, framework documentation, or technical documentation lookup. Provides up-to-date, version-specific docs and code examples.

Creates, edits, and manages Obsidian vault content including notes, templates, daily notes, and dataview queries. Use when working with markdown files in an Obsidian vault, creating notes, writing templates, building dataview queries, or organizing knowledge management content.

This skill should be used when writing in the distinctive style of David Heinemeier Hansson (DHH). It applies when creating blog posts, technical articles, business content, manifestos, or any prose requiring a clear, punchy, opinionated style.