Mendelian Randomization in R

Overview

Mendelian randomization (MR) methods for causal inference using genetic variants as instrumental variables. Covers instrument selection, two-sample MR, sensitivity analyses, pleiotropy assessment, multivariable MR, and advanced methods for robust causal inference.

Instrument Selection

Using TwoSampleMR

library(TwoSampleMR)

# Extract instruments from GWAS database
# IEU Open GWAS Project
exposure_dat <- extract_instruments(
  outcomes =

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