Multiplicity Methods
When to Use This Skill
- Selecting appropriate multiplicity adjustment procedures
- Implementing gatekeeping for primary/secondary endpoints
- Designing graphical testing procedures
- Optimizing truncation parameters (gamma)
- Ensuring FWER control in multi-arm/multi-endpoint trials
Fundamental Concepts
Family-Wise Error Rate (FWER)
FWER = P(reject at least one true null hypothesis)
Multiplicity adjustments control FWER at level α (typically 0.025 one-sided
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