Gene Regulatory Network Inference
GRN vs PPI Networks
| Aspect | PPI Network | GRN | |--------|-------------|-----| | Edges | Physical protein binding | Transcriptional regulation | | Direction | Undirected | Directed (TF → target) | | Data source | Y2H, co-IP | Expression + ChIP-seq | | Databases | STRING, BioGRID | TRRUST, ChEA, DoRothEA |
Method Comparison
| Method | Captures | Pros | Cons | |--------|----------|------|------| | Pearson/Spearman correlation | Linear co-variation |
[Description truncada. Veja o README completo no GitHub.]