Viral Genome Assembly and Variant Analysis
Sequencing Strategy Selection
| Strategy | Description | Use case | |----------|-------------|----------| | Amplicon (ARTIC) | Tiling PCR from known reference | SARS-CoV-2, HIV, Influenza | | Metagenomic (shotgun) | Unbiased, needs host depletion | Novel/unknown pathogens | | Hybrid capture | Probe enrichment | Low-titer (hepatitis, low-level viremia) |
Key distinction from bacterial/human assembly: viruses exist as quasispecies — a clou
[Description truncada. Veja o README completo no GitHub.]