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bio-causal-genomics-pleiotropy-detection

Detect and adjust for horizontal pleiotropy in two-sample Mendelian randomization by distinguishing uncorrelated (UHP) from correlated (CHP) pleiotropy and choosing among Egger, MR-PRESSO, MR-RAPS, CAUSE, LHC-MR, LCV, MR-Clust, MR-Mix, and contamination-mixture methods. Use when validating an MR causal claim, running the STROBE-MR sensitivity battery, suspecting a shared heritable confounder, work

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Atualizado há 4 meses

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Version Compatibility

Reference examples tested with: TwoSampleMR 0.5.11+, MendelianRandomization 0.9.0+, MR-PRESSO 1.0+, CAUSE 1.2.0+, MR-Clust 0.1.0+, MRMix 0.1+, mr.raps 0.4.1+ (GitHub), LHC-MR 0.0.0.9000+ (GitHub), LCV (script-based, no version tag), simex 1.8+.

Before using code patterns, verify installed versions match. If versions differ:

  • R: packageVersion('<pkg>') then ?function_name to verify parameters
  • For GitHub-only packages, check the repo HEAD vs the local install date

[Description truncada. Veja o README completo no GitHub.]

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