DepMap CRISPR gene effect (Chronos) analysis: sign convention for essentiality, per-gene NaN-safe Spearman correlation, data loading/alignment. For general NaN-safe correlation see nan-safe-correlation; for quality filtering see degenerate-input-filtering.
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DepMap CRISPR Gene Effect Analysis Guide
Overview
This guide covers the correct interpretation and analysis of DepMap CRISPR gene effect (Chronos) data. The most critical and common error in DepMap analyses is failing to negate the CRISPR scores when computing correlations with "essentiality." A secondary but equally damaging mistake is using bulk correlation shortcuts that mishandle per-gene NaN patterns. This guide provides the mandatory sign convention, the correct per-gene NaN-safe Sp
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