KEGG Pathway Enrichment Analysis Guide
Overview
KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway enrichment analysis identifies biological pathways that are statistically over-represented among differentially expressed genes. This guide covers the two main enrichment approaches (ORA and GSEA), critical workflow decisions such as splitting genes by directionality, tool selection between R clusterProfiler and Python gseapy, and strategies for handling the notoriously unreliable KEGG R
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