PharmGKB Annotator Skill
Purpose
Provide PharmGKB pharmacogenomics annotation for drug-gene interaction assessment.
Capabilities
- Star allele calling (Stargazer)
- Diplotype determination
- CPIC guideline integration
- Drug recommendation generation
- Clinical annotation lookup
- Dosing guidance extraction
Usage Guidelines
- Call star alleles accurately
- Determine diplotypes from genotypes
- Apply CPIC guidelines for dosing
- Generate actionable recommendations
- Review clinical annotations
- Document guideline versions
Dependencies
- PharmGKB API
- Stargazer
- PharmCAT
Process Integration
- Pharmacogenomics Analysis (pharmacogenomics-analysis)
- Clinical Variant Interpretation (clinical-variant-interpretation)