PubChem Compound Search
Overview
PubChem (NCBI) is the largest freely available chemical database — 110M+ compounds, 280M+ substances, and millions of bioassay records. Its PUG-REST JSON API is the canonical programmatic surface, and every example here uses it directly via plain requests. The Python pubchempy wrapper is not required; the PUG-REST URL grammar is small enough that direct calls are more transparent, easier to retry/cache, and avoid sandbox dependency issues (the li
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