Prioritize drug targets from a ranked gene list (e.g., scRNA-seq DE output) by orchestrating parallel API queries against UniProt, OpenTargets (with integrated DepMap CRISPR essentiality + gnomAD constraint), PubMed, the Human Protein Atlas (HPA), and ChEMBL tool compounds, then re-ranking by a composite score combining protein localization, druggability, disease genetics, tissue specificity (safe
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Target Prioritization
A multi-source drug-target due-diligence pipeline for ranked gene lists.
When this skill triggers
The user has a list of candidate genes (typically from a DE / DEG / scRNA-seq analysis) and wants a per-gene dossier across multiple evidence dimensions plus a composite re-ranking. The DE statistical rank is just the entry point; the final priority is informed by protein biology, genetics, druggability, and research maturity.
Common input shapes:
A CSV with a gene
[Description truncada. Veja o README completo no GitHub.]
