Time-to-Event Methods
When to Use This Skill
- Selecting appropriate analysis methods for survival endpoints
- Handling non-proportional hazards scenarios
- Implementing weighted logrank tests
- Designing MaxCombo tests
- Using RMST or milestone endpoints
Analysis Methods Overview
Standard Logrank Test
When Optimal:
- Proportional hazards assumption holds
- Treatment effect constant over time
Formula:
Z = Σ(O_trt - E_trt) / √(Var)
simtrial Implementation: `
[Description truncada. Veja o README completo no GitHub.]