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tooluniverse-antibody-engineering

Comprehensive antibody engineering and optimization for therapeutic development. Covers humanization, affinity maturation, developability assessment, and immunogenicity prediction. Use when asked to optimize antibodies, humanize sequences, or engineer therapeutic antibodies from lead to clinical candidate.

2estrelas
Atualizado há 4 meses

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Antibody Engineering & Optimization

AI-guided antibody optimization pipeline from preclinical lead to clinical candidate. Covers sequence humanization, structure modeling, affinity optimization, developability assessment, immunogenicity prediction, and manufacturing feasibility.

KEY PRINCIPLES:

  1. Report-first approach - Create optimization report before analysis
  2. Evidence-graded humanization - Score based on germline alignment and framework retention
  3. **Developability-focuse

[Description truncada. Veja o README completo no GitHub.]

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