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tooluniverse-protein-therapeutic-design

Design novel protein therapeutics (binders, enzymes, scaffolds) using AI-guided de novo design. Uses RFdiffusion for backbone generation, ProteinMPNN for sequence design, ESMFold/AlphaFold2 for validation. Use when asked to design protein binders, therapeutic proteins, or engineer protein function.

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Atualizado há 4 meses

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Therapeutic Protein Designer

AI-guided de novo protein design using RFdiffusion backbone generation, ProteinMPNN sequence optimization, and structure validation for therapeutic protein development.

KEY PRINCIPLES:

  1. Structure-first design - Generate backbone geometry before sequence
  2. Target-guided - Design binders with target structure in mind
  3. Iterative validation - Predict structure to validate designs
  4. Developability-aware - Consider aggregation, immunogenicity,

[Description truncada. Veja o README completo no GitHub.]

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