Desenvolvimento

Differential gene expression analysis (Python DESeq2). Identify DE genes from bulk RNA-seq counts, Wald tests, FDR correction, volcano/MA plots, for RNA-seq analysis.

Analyzes Claude Code usage patterns and provides comprehensive recommendations. Runs usage analysis, discovers GitHub community resources, suggests CLAUDE.md improvements, and fetches latest docs on-demand. Use when user wants to optimize their Claude Code workflow, create configurations (agents/skills/commands), or set up project documentation.

Write Ruby gems following Andrew Kane's proven patterns and philosophy. Use when creating new Ruby gems, refactoring existing gems, designing gem APIs, or when the user wants clean, minimal, production-ready Ruby library code. Triggers on requests like "create a gem", "write a Ruby library", "design a gem API", or mentions of Andrew Kane's style.

Master effective code review practices to provide constructive feedback, catch bugs early, and foster knowledge sharing while maintaining team morale. Use when reviewing pull requests, establishing review standards, or mentoring developers.

Comprehensive truth scoring, code quality verification, and automatic rollback system with 0.95 accuracy threshold for ensuring high-quality agent outputs and codebase reliability.

Guide Clojure and ClojureScript development using REPL-driven workflow, coding conventions, and best practices. Use when writing, developing, or refactoring Clojure/ClojureScript code.

Review TypeScript and JavaScript code changes for compliance with Metabase coding standards, style violations, and code quality issues. Use when reviewing pull requests or diffs containing TypeScript/JavaScript code.

Track progress across work sessions using SESSION.md with git checkpoints and concrete next actions. Converts IMPLEMENTATION_PHASES.md into trackable session state with phase status, progress markers, and recovery points. Use when: starting projects after planning phase, resuming work after context clears, managing multi-phase implementations, or troubleshooting lost context, missing progress trac

Review Clojure and ClojureScript code changes for compliance with Metabase coding standards, style violations, and code quality issues. Use when reviewing pull requests or diffs containing Clojure/ClojureScript code.

Master systematic debugging techniques, profiling tools, and root cause analysis to efficiently track down bugs across any codebase or technology stack. Use when investigating bugs, performance issues, or unexpected behavior.

Test authenticated routes in the your project using cookie-based authentication. Use this skill when testing API endpoints, validating route functionality, or debugging authentication issues. Includes patterns for using test-auth-route.js and mock authentication.

Testing patterns for PHPUnit and Playwright E2E tests. Use when writing tests, debugging test failures, setting up test coverage, or implementing test patterns for ActivityPub features.