Design e Frontend

Create production-ready FastAPI projects with async patterns, dependency injection, and comprehensive error handling. Use when building new FastAPI applications or setting up backend API projects.

This skill should be used when the user asks to "create a hookify rule", "write a hook rule", "configure hookify", "add a hookify rule", or needs guidance on hookify rule syntax and patterns.

Full website GEO+SEO audit with parallel subagent delegation. Orchestrates a comprehensive Generative Engine Optimization audit across AI citability, platform analysis, technical infrastructure, content quality, and schema markup. Produces a composite GEO Score (0-100) with prioritized action plan.

AI-powered cell-free RNA analysis from liquid biopsy for cancer detection, tissue-of-origin identification, and non-invasive transcriptomic profiling.

Enumerates virtual chemical libraries via reaction SMARTS transformations using RDKit and Reaction templates, with explicit handling of atom mapping, template extraction (RDKit reaction mining), product validation, RECAP/BRICS fragmentation, R-group decomposition, matched molecular pair analysis (MMPA), and Free-Wilson analysis. Use when generating combinatorial libraries from building blocks, enu

Phase genotypes into haplotypes using Beagle or SHAPEIT. Resolves which alleles are inherited together on each chromosome. Use when preparing VCF files for imputation, HLA typing, or population genetic analyses requiring phased haplotypes.

Query decomposition and multi-source search orchestration. Breaks natural language questions into targeted searches per source, translates queries into source-specific syntax, ranks results by relevance, and handles ambiguity and fallback strategies.

Designs Bayesian clinical trials including Phase I dose-finding (BOIN, CRM, EWOC, mTPI-2), meta-analytic-predictive (MAP) priors with robust mixtures for external data borrowing, EXNEX for basket trials, hierarchical models for safety AE (Berry-Berry), Bayesian platform trials (I-SPY 2, GBM AGILE, REMAP-CAP), and posterior probability stopping rules. Covers FDA Bayesian Devices Guidance (2010), FD

Master iOS Human Interface Guidelines and SwiftUI patterns for building native iOS apps. Use when designing iOS interfaces, implementing SwiftUI views, or ensuring apps follow Apple's design principles.

Explore and optimize simulation parameters via design of experiments (DOE), sensitivity analysis, and optimizer selection. Use for calibration, uncertainty studies, parameter sweeps, LHS sampling, Sobol analysis, surrogate modeling, or Bayesian optimization setup.

Reading and managing Gmail emails - Sending emails with attachments - Replying to emails while maintaining thread continuity

Manage breaking API changes, migration guides, deprecation notices, and semver versioning. Use when introducing breaking changes, writing migration paths, updating changelogs, or releasing major versions.