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Cross-language REST conventions — resource URLs, method semantics, status codes, URL-prefix versioning, cursor pagination, snake_case JSON, ISO 8601 timestamps, RFC 7807 errors, Idempotency-Key, ETag/If-Match, OpenAPI as source of truth. Framework-agnostic. Use when designing or auditing REST endpoints.

Sequence-based deep learning for ATAC-seq using chromBPNet, BPNet, scBasset, or EnFormer. Use when correcting Tn5 bias with neural networks beyond k-mer models, predicting per-base accessibility profiles, scoring in silico variant effects at GWAS or rare-variant SNPs, discovering motifs via DeepLIFT/TF-MoDISco from a trained model, or generating cell-type-specific accessibility predictions for uno

· Audit read-only code slimming: safe deletion, deduplication, wrapper removal, shared contracts. Triggers: 'slim codebase', 'LOC deletion review', 'dedupe safely'. Not for style/slop, bugs, tests, or broad reviews.

Create Mermaid diagrams for flowcharts, sequences, ERDs, and

Obsidian content curation and quality specialist. Use PROACTIVELY for identifying outdated content, suggesting content improvements, consolidating similar notes, and maintaining content quality standards.

AI-powered analysis of T-cell exhaustion states, epigenetic scarring, stem-like T-cell populations, and checkpoint blockade response prediction in cancer immunotherapy.

Formate referências profissionais corretamente e prepare materiais de referência.

JetBrains Exposed ORM patterns including DSL queries, DAO pattern, transactions, HikariCP connection pooling, Flyway migrations, and repository pattern.

Use when building UI components. Enforces ShadCN UI patterns, accessibility standards (Radix UI), and TailwindCSS best practices for November 2025.

Migrate prompts and code from Claude Sonnet 4.0, Sonnet 4.5, or Opus 4.1 to Opus 4.5. Use when the user wants to update their codebase, prompts, or API calls to use Opus 4.5. Handles model string updates and prompt adjustments for known Opus 4.5 behavioral differences. Does NOT migrate Haiku 4.5.

When the user wants to create, optimize, or audit FAQ page content. Also use when the user mentions "FAQ page," "frequently asked questions," "help page," "Q&A page," "FAQ schema," "FAQ section," "common questions," "FAQ SEO," "accordion FAQ," "People Also Ask," "PAA," "People Also Search For," "PASF," or "FAQ rich results." For FAQ structured data markup, use schema-markup. For AI search visibili

Use when encountering any bug, test failure, or unexpected behavior, before proposing fixes