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Enumerates virtual chemical libraries via reaction SMARTS transformations using RDKit and Reaction templates, with explicit handling of atom mapping, template extraction (RDKit reaction mining), product validation, RECAP/BRICS fragmentation, R-group decomposition, matched molecular pair analysis (MMPA), and Free-Wilson analysis. Use when generating combinatorial libraries from building blocks, enu

Write-time code quality enforcement using Plankton — auto-formatting, linting, and Claude-powered fixes on every file edit via hooks.

Cleans up and organizes project files. Use when user mentions '整理', 'cleanup', 'アーカイブ', 'archive', '肥大化', 'Plans.md', 'session-log', or asks to clean up old tasks, archive completed items, or organize files. Do NOT load for: 実装作業, レビュー, 新機能開発, デプロイ.

Score deal velocity based on email response times, meeting frequency, and stakeholder engagement. Predict which deals will close vs stall.

Conversão de texto em fala usando o serviço GLM-TTS via comando `uvx zai-tts` para gerar áudio a partir de texto. Utilize quando o usuário solicitar saída de áudio/voz com o gatilho ou palavra-chave "tts", ou quando o conteúdo precisar ser falado em vez de lido, especialmente com vozes pré-clonadas.

Bayesian modeling with PyMC 5: priors, likelihood, NUTS/ADVI sampling, diagnostics (R-hat, ESS), LOO/WAIC comparison, prediction. Hierarchical, logistic, GP variants; predictive checks.

Esta skill é usada para traduzir, revisar ou manter traduções de UI e documentos para Sindarin ou Quenya (línguas élficas de Tolkien). Ela utiliza o léxico Eldamo empacotado para tarefas como trabalhar com arquivos de localização, traduzir do inglês para élfico ou revisar traduções existentes.

Comprehensive drug-drug interaction (DDI) prediction and risk assessment. Analyzes interaction mechanisms (CYP450, transporters, pharmacodynamic), severity classification, clinical evidence grading, and provides management strategies. Supports single drug pairs, polypharmacy analysis (3+ drugs), and alternative drug recommendations. Use when users ask about drug interactions, medication safety, po

RouterOS firewall filter, NAT, mangle, and address-list configuration. Use when: writing firewall rules in RouterOS, configuring NAT, setting up address-lists or interface-lists, writing idempotent firewall scripts, configuring DNS redirect or port forwarding, or when the user mentions /ip/firewall, chain=forward, chain=input, connection-state, address-list, interface-list, or layer7-protocol on M

Web search and content extraction with Tavily and Exa via inference.sh CLI. Apps: Tavily Search, Tavily Extract, Exa Search, Exa Answer, Exa Extract. Capabilities: AI-powered search, content extraction, direct answers, research. Use for: research, RAG pipelines, fact-checking, content aggregation, agents. Triggers: web search, tavily, exa, search api, content extraction, research, internet search,

Explore and optimize simulation parameters via design of experiments (DOE), sensitivity analysis, and optimizer selection. Use for calibration, uncertainty studies, parameter sweeps, LHS sampling, Sobol analysis, surrogate modeling, or Bayesian optimization setup.

Reading and managing Gmail emails - Sending emails with attachments - Replying to emails while maintaining thread continuity