Explorar skills

Use this skill when working with Twilio communication APIs for SMS/MMS messaging, voice calls, phone number management, TwiML, webhook integration, two-way SMS conversations, bulk sending, or production deployment of telephony features. Includes official Twilio patterns, production code examples from Twilio-Aldea (provider-agnostic webhooks, signature validation, TwiML responses), and comprehensiv

Guide for annotating ENCODE peaks with genomic features using ChIPseeker and GREAT. Use when users need to assign peaks to genes, determine genomic feature distribution (promoter, intron, intergenic), or perform gene ontology enrichment of peak-associated genes. Trigger on: peak annotation, ChIPseeker, GREAT, peak to gene, genomic feature, promoter enrichment, gene ontology, peak distribution, TSS

Discover and characterize regulatory elements (enhancers, promoters, silencers, insulators, super-enhancers) using ENCODE data and the cCRE catalog. Use when the user wants to find candidate regulatory elements, identify active enhancers in a tissue, map promoter states, classify chromatin states with ChromHMM, identify super-enhancers with ROSE, understand the functional validation hierarchy (CRI

Build comprehensive histone mark maps by aggregating narrowPeak data across multiple ENCODE experiments, donors, and labs. Use when the user wants to answer "where is this histone mark present in my tissue?" by combining peak calls from multiple studies into a union peak set with confidence annotations. Handles cross-lab batch effects, broad vs narrow marks, and ENCODE blocklist filtering.

Cross-reference ENCODE data with PubMed, bioRxiv, ClinicalTrials.gov, Open Targets, GTEx, ClinVar, GWAS Catalog, gnomAD, Ensembl, and other scientific databases. Use when the user wants to find publications, preprints, or clinical trials related to ENCODE experiments, chain ENCODE data with other scientific MCP servers, or build translational pipelines from genomic data to clinical application.

Compare ENCODE experiments across different biosamples, tissues, or cell lines to identify tissue-specific regulatory patterns. Use when the user wants cross-tissue comparison, cell-type comparison, tissue-specific elements, differential chromatin, biosample matching, disease vs normal comparison, developmental time course, constitutive vs variable regulation, or multi-tissue data availability map

Coordinate software development work by analyzing requirements, delegating tasks to specialized sub-agents (developer, code-reviewer, tester), and synthesizing their work into cohesive deliverables. Use this for complex projects that require multiple specialized perspectives.

Use to conduct STRIDE threat modeling for a system or feature design.

Use to verify a feature/story meets all Definition of Done criteria before marking complete.

Use before starting delivery work. Pre-implementation validation checklist to ensure readiness.

Query gnomAD (Genome Aggregation Database) for population allele frequencies, gene constraint scores, and variant annotations to interpret ENCODE regulatory variants. Use when the user needs allele frequencies for variants in ENCODE regulatory elements, wants to assess gene constraint (pLI, LOEUF) for ENCODE target genes, needs population-specific frequencies for GWAS variants overlapping cCREs, w

Explainability (XAI) audit for products containing AI components. Five-stage tier-scaled check: risk classification, stakeholder×question matrix, fidelity audit, system card, recourse path. Honest about what was validated functionally vs what needs user testing.