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Multi-Omics Factor Analysis v2 (MOFA+) with mofapy2. Jointly decompose omics layers (scRNA, ATAC, proteomics, methylation) into latent factors capturing major variation. Multi-group designs. AnnData views → MOFA object → train → variance explained → correlate factors with metadata → visualize/cluster → enrich top loadings.

SwiftUI architecture patterns, state management with @Observable, view composition, navigation, performance optimization, and modern iOS/macOS UI best practices.

Design and implement microinteractions, motion design, transitions, and user feedback patterns. Use when adding polish to UI interactions, implementing loading states, or creating delightful user experiences.

Structured hypothesis formulation from observations. Use when you have experimental observations or data and need to formulate testable hypotheses with predictions, propose mechanisms, and design experiments to test them. Follows scientific method framework. For open-ended ideation use scientific-brainstorming; for automated LLM-driven hypothesis testing on datasets use hypogenic.

Consultar a API openFDA para dados sobre medicamentos, dispositivos, eventos adversos, recalls, submissões regulatórias (510k, PMA) e identificação de substâncias (UNII), visando análise de dados regulatórios da FDA e pesquisa de segurança.

Freshworks CRM integration via Apideck's CRM unified API — same methods work across every connector in CRM, switch by changing `serviceId`. Use when the user wants to read, write, or search contacts, companies, leads, opportunities, activities, and pipelines in Freshworks CRM. Routes through Apideck with serviceId "freshsales".

Create components using ng-alain (@delon/abc) and ng-zorro-antd UI libraries. Use this skill when building enterprise UI features with ST (Simple Table), SF (Schema Form), ACL (Access Control), PageHeader, ReuseTab, and other @delon components. Ensures proper integration with ng-alain architecture, theming system, responsive layouts, and accessibility standards while following Angular 20 patterns.

Gera um dossiê de pesquisa de mercado impresso (HTML + PDF de 8 páginas) para o comprador levar ao concessionário durante o test drive, resumindo o perfil do comprador, comparativos regionais, preço final desejado e referências para contrapropostas.

Use when creating or publishing Claude Code hooks - covers executable format, event types, JSON I/O, exit codes, security requirements, and PRPM package structure

Picqer integration via Apideck's Ecommerce unified API — same methods work across every connector in Ecommerce, switch by changing `serviceId`. Use when the user wants to read, write, or sync orders, products, customers, and stores in Picqer. Routes through Apideck with serviceId "picqer".

Install and wire registry blocks and components into HyperFrames compositions. Use when running hyperframes add, installing a block or component, wiring an installed item into index.html, or working with hyperframes.json. Covers the add command, install locations, block sub-composition wiring, component snippet merging, and registry discovery.

Plan Zentao tasks, and perform Zentao operations including creating tasks, logging work hours, and completing tasks.规划禅道任务，以及对禅道操作，创建任务、录入工时、完成任务。