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Designs experiments to minimize and account for batch effects using balanced layouts and blocking strategies. Use when planning multi-batch experiments, assigning samples to sequencing lanes, or designing studies where technical variation could confound biological signals.

Comprehensive Excel spreadsheet creation, editing, and analysis with support for formulas, formatting, charts, data analysis, and visualization. Use when working with .xlsx, .xlsm, .csv files for: (1) Creating spreadsheets with formulas and formatting, (2) Reading/analyzing data, (3) Modifying existing spreadsheets while preserving formulas, (4) Creating charts and visualizations, (5) Data transfo

Combine vector and keyword search for improved retrieval. Use when implementing RAG systems, building search engines, or when neither approach alone provides sufficient recall.

Build scalable design systems with design tokens, theming infrastructure, and component architecture patterns. Use when creating design tokens, implementing theme switching, building component libraries, or establishing design system foundations.

End-to-end gene regulatory network inference pipeline from processed single-cell data to regulon discovery and perturbation simulation. Supports RNA-only (pySCENIC) and multiome (SCENIC+) paths. Use when building gene regulatory networks from single-cell transcriptomic or multiome data.

End-to-end Ribo-seq analysis from FASTQ to translation efficiency and ORF detection. Use when analyzing ribosome profiling data to study translation.

Manages release preparation including validation, version bumping, documentation verification, and security checks.

Builds and applies 3D pharmacophore models using RDKit Pharm3D, the apo2ph4 receptor-based workflow (Heider et al 2022/2023 J Chem Inf Model 63:147-158), Pharmer / Pharmit (search), and PharmacoForge (diffusion-based generation, Flynn et al 2025 Front Bioinform), covering ligand-based pharmacophore (from active set alignment) and receptor-based pharmacophore (from binding pocket geometry). Explici

Improves the quality of images, especially screenshots, by enhancing resolution, sharpness, and clarity. Perfect for preparing images for presentations, documentation, or social media posts.

Comprehensive quality verification and validation through static analysis, dynamic testing, integration validation, and certification gates

Create employment contracts, offer letters, and HR policy documents following legal best practices. Use when drafting employment agreements, creating HR policies, or standardizing employment documentation.

Codex Pet generator on RunComfy. Build a Codex-compatible Codex Pet spritesheet.webp + pet.json from a single reference image, drop it into `${CODEX_HOME:-$HOME/.codex}/pets/<name>/` and Codex picks it up as a custom Codex Pet next to the 8 built-ins. This skill produces the exact Codex Pet atlas Codex expects (1536x1872 PNG/WebP, 8 cols x 9 rows, 192x208 cells, 9 animation states — idle, running-