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Identify likely causal variants within GWAS loci using SuSiE for sum of single effects regression and FINEMAP for shotgun stochastic search. Computes posterior inclusion probabilities and credible sets to prioritize variants for functional follow-up. Use when narrowing GWAS association signals to candidate causal variants or building credible sets for functional validation.

Game design principles. GDD structure, balancing, player psychology, progression.

Conduct WCAG 2.2 accessibility audits with automated testing, manual verification, and remediation guidance. Use when auditing websites for accessibility, fixing WCAG violations, or implementing accessible design patterns.

Senhasegura PAM platform integration — A2A OAuth 2.0, PAM Core credentials, SSH key rotation, DSM CLI for CI/CD, External Secrets Operator (Kubernetes), MySafe, and a runnable MCP server. USE WHEN senhasegura, segura, A2A application, DSM CLI, runb, MySafe, ExternalSecret + senhasegura, OAuth client_credentials for PAM, credential custody release, /iso/coe/senha endpoint, SCIM provisioning. NOT FO

Extract, analyze, and visualize simulation output data. Use for field extraction, time series analysis, line profiles, statistical summaries, derived quantity computation, result comparison to references, and automated report generation from simulation results.

Run Nx generators with prioritization for workspace-plugin generators. Use this when generating code, scaffolding new features, or automating repetitive tasks in the monorepo.

Statistical visualization with pandas integration. Use for quick exploration of distributions, relationships, and categorical comparisons with attractive defaults. Best for box plots, violin plots, pair plots, heatmaps. Built on matplotlib. For interactive plots use plotly; for publication styling use scientific-visualization.

Design like a high-end agency with exact fonts, spacing, shadows, card structures, and animations that make websites feel expensive. Use when the user wants premium visual quality, "make it look expensive", agency-level design, or cinematic spatial rhythm.

Gerar análise abrangente de oportunidade de mercado com TAM/SAM/SOM.

Provide actionable treatment recommendations for cancer patients based on molecular profile. Interprets tumor mutations, identifies FDA-approved therapies, finds resistance mechanisms, matches clinical trials. Use when oncologist asks about treatment options for specific mutations (EGFR, KRAS, BRAF, etc.), therapy resistance, or clinical trial eligibility.

This skill should be used as the entry gate for build/create/implement requests. Triggers on "build X", "create Y", "implement Z", "add feature", "try both approaches", "not sure which approach". Offers brainstorm-together or omakase (chef's choice parallel exploration) options. Detects indecision during brainstorming to offer parallel exploration.

React useEffect best practices from official docs. Use when writing/reviewing useEffect, useState for derived values, data fetching, or state synchronization. Teaches when NOT to use Effect and better alternatives.