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End-to-end clinical trial analysis workflow from CDISC SDTM/ADaM loading through ICH E9(R1) estimand-driven primary analysis to CONSORT 2025 regulatory-compliant reporting. Covers data preparation, FDA 2023 marginal vs conditional logistic regression, categorical tests with Boschloo, modern HTE/subgroup methods, missing-data sensitivity (MMRM, reference-based MI, Permutt tipping point), graphical

Consulta a API REST do banco de dados genômico Ensembl para mais de 250 espécies. Permite buscas de genes, recuperação de sequências, análise de variantes, genômica comparativa, ortólogos e previsões VEP para pesquisa genômica.

Analyze spreads, over/unders, prop bets. Historical trends, situational stats, value bet identification. For entertainment/education only.

Auto-loaded context for Portfolio Buddy 2 development. Use for ANY task involving: React 19 development, TypeScript, portfolio analysis features, metrics calculations, trading strategy comparison, or working with the Portfolio Buddy 2 codebase. Contains tech stack, known issues, and architectural constraints.

Use PROACTIVELY when you need to create, update, configure, or validate Claude hooks for various events and integrations

Generate a custom checklist for the current feature based on user requirements.

Build reusable Terraform modules for AWS, Azure, GCP, and OCI infrastructure following infrastructure-as-code best practices. Use when creating infrastructure modules, standardizing cloud provisioning, or implementing reusable IaC components.

World-class prompt engineering skill for LLM optimization, prompt patterns, structured outputs, and AI product development. Expertise in Claude, GPT-4, prompt design patterns, few-shot learning, chain-of-thought, and AI evaluation. Includes RAG optimization, agent design, and LLM system architecture. Use when building AI products, optimizing LLM performance, designing agentic systems, or implement

Python testing with pytest using uv package manager. Use when: (1) Running Python tests, (2) Writing test files or test functions, (3) Setting up fixtures, (4) Parametrizing tests, (5) Generating coverage reports, (6) Testing FastAPI applications, (7) Debugging test failures, (8) Configuring pytest options. Triggers: "run tests", "write tests", "test coverage", "pytest", "unit test", "integration

Joint genotype calling across multiple samples using GATK CombineGVCFs and GenotypeGVCFs. Essential for cohort studies, population genetics, and leveraging VQSR. Use when performing joint genotyping across multiple samples.

Gerencia infraestrutura de TI, monitoramento, resposta a incidentes e confiabilidade de serviços. Fornece estruturas para gerenciamento de serviços ITIL, estratégias de observabilidade, automação, backup/recuperação, planejamento de capacidade e práticas de excelência operacional.

Manual and automated gating for defining cell populations in flow cytometry. Covers rectangular, polygon, and data-driven gates. Use when identifying cell populations through hierarchical gating strategies.