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Performs set operations on genomic intervals - intersect (-wa/-wb/-wo/-wao/-loj/-c/-v/-u), subtract (-A), merge (-d, -c/-o), complement, cluster, multiinter, unionbedg, map, and groupby - with bedtools (CLI) and pybedtools/pyranges/bioframe (Python). Covers the sorted-input contract and the -sorted chromosome-order footgun, reciprocal/fractional overlap (-f/-F/-r/-e) and the A-vs-B asymmetry, -spl

Differential gene expression analysis (Python DESeq2). Identify DE genes from bulk RNA-seq counts, Wald tests, FDR correction, volcano/MA plots, for RNA-seq analysis.

Standardizes molecular structures using ChEMBL chembl_structure_pipeline and RDKit rdMolStandardize covering sanitization, salt/solvent stripping, neutralization, tautomer canonicalization, stereochemistry standardization, mixture handling, and isotope normalization. Explicitly compares ChEMBL pipeline, canSARchem, and PubChem standardization choices. Use when preparing libraries for QSAR training

全球最大的 Claude Code 技能聚合库 · 收录 3900+ 来自 12+ 来源的技能，提供在线搜索与趋势分析看板 / The world's largest Claude Code skill aggregation hub — 3900+ skills from 12+ sources with online search and trend dashboard

Audit and improve web accessibility following WCAG 2.2 guidelines. Use when asked to "improve accessibility", "a11y audit", "WCAG compliance", "screen reader support", "keyboard navigation", or "make accessible".

Model product UI actions from user intent questions after a meaningful outcome, completion, created resource, imported data, uploaded file, synced integration, report, deployment, automation, review state, handoff, or workflow milestone. Use when deciding which actions to show, hide, group, name, prioritize, defer, or place across outcome, item, selection, continuation, navigation, recovery, and a

Optimize landing pages for conversions, performance, and SEO. Use when improving landing pages, increasing conversions, or optimizing page performance.

Configure Turborepo for efficient monorepo builds with local and remote caching. Use when setting up Turborepo, optimizing build pipelines, or implementing distributed caching.

Guide to quality filtering raw VCF files before computing summary stats (Ts/Tv ratio, variant counts, AF distributions). Covers detecting raw VCFs via FILTER column and QUAL inspection, QUAL-based filtering with bcftools, Ts/Tv interpretation, and when NOT to filter. Read before any variant-level QC task. See bcftools-variant-manipulation for advanced filters, gatk-variant-calling for caller confi

全球最大的 Claude Code 技能聚合库 · 收录 3900+ 来自 12+ 来源的技能，提供在线搜索与趋势分析看板 / The world's largest Claude Code skill aggregation hub — 3900+ skills from 12+ sources with online search and trend dashboard

Pesquise no repositório de pré-publicações arXiv por artigos em física, matemática, ciência da computação, biologia quantitativa e áreas relacionadas.

Python design patterns including KISS, Separation of Concerns, Single Responsibility, and composition over inheritance. Use this skill when designing a new service or component from scratch and choosing how to layer responsibilities, when refactoring a God class or monolithic function that has grown too large, when deciding whether to add a new abstraction or live with duplication, when evaluating