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Escreva código C eficiente com gerenciamento de memória adequado e uso de ponteiros.

PR作成Skill。仕様レビュー用または実装レビュー用のPRを作成。/spec や spec-workflow から呼び出される。

Runs JACKS (Joint Analysis of CRISPR/Cas9 Knockout Screens; Allen et al 2019 Genome Research) which models per-sgRNA log-fold-change as the product of a treatment-dependent gene-essentiality term and a treatment-independent guide-efficacy term. Covers the Bayesian decomposition math, the hierarchical efficacy prior shared across screens performed with the same library, when JACKS outperforms MAGeC

UMAP dimensionality reduction for visualization, clustering prep, and feature engineering. Fast nonlinear manifold learning preserving local and global structure. Standard UMAP (fit/transform, sklearn-compatible), supervised/semi-supervised, Parametric UMAP (NN encoder/decoder, TensorFlow), DensMAP (density), AlignedUMAP (temporal/batch). 15+ distance metrics, custom Numba metrics, precomputed dis

Apple HIG guidance for navigation-related components including search fields, page controls, and path controls. Use this skill when the user says "how should search work in my app," "I need a breadcrumb," "how do I paginate content," or asks about search field, search bar, page control, path control, breadcrumb, navigation component, search UX, search suggestions, search scopes, paginated content

Test-Driven Development workflow - write tests first, then implementation

Executive communication style for all-hands emails. Balances transparency with appropriate messaging.

API + Python SDK for ordering cell-free protein expression and binding assays. Submit sequences for expression (10–100 µg), measure binding affinity (KD) against targets, track status, and retrieve results programmatically — no wet-lab setup. Built for ML-guided directed evolution and antibody/nanobody optimization. Requires Adaptyv account and API key.

Analyzes base editing and prime editing outcomes including editing efficiency, bystander edits, and indel frequencies. Use when quantifying CRISPR base editor results, comparing ABE vs CBE efficiency, or assessing prime editing fidelity.

Best practices and patterns for Next.js App Router, Server Actions, and Routing in this project.

Build full-paper Chinese-English side-by-side, figure/table-aware, source-grounded Markdown readers for journal or conference papers from PDF, DOI, arXiv, publisher HTML, or pasted text. Use whenever the user asks to translate or read a paper, make 中英文对照/原文对照/全文翻译解读, extract figures or tables into the right positions, preserve figure/table placement near relevant prose, or keep exact source anchor

Parse trial protocols and patient data to produce criterion-level MET/NOT/UNKNOWN determinations with evidence and gaps for clinical trial screening tasks.