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Identifies differentially bound ChIP-seq regions between conditions using DiffBind, csaw (sliding windows), DESeq2/edgeR/PyDESeq2 on count matrices, NormR (control-aware), or MAnorm2. Distinguishes three distinct normalization problems (composition bias, trended bias, global shifts) and matches each to its appropriate fix including spike-in scaling. Use when comparing ChIP-seq binding between expe

Analyzes git commit history and generates structured changelogs categorized by change type. Use when the user asks about recent changes, wants a changelog, or needs to understand what changed in the repository.

Load gene expression count matrices from various formats including CSV, TSV, featureCounts, Salmon, kallisto, and 10X. Use when importing quantification results for downstream analysis.

全球最大的 Claude Code 技能聚合库 · 收录 3900+ 来自 12+ 来源的技能，提供在线搜索与趋势分析看板 / The world's largest Claude Code skill aggregation hub — 3900+ skills from 12+ sources with online search and trend dashboard

Efficiently add Malli schemas to API endpoints in the Metabase codebase with proper patterns, validation timing, and error handling

Manages Tilt development environments via CLI and Tiltfile authoring. Must use when working with Tilt or Tiltfiles.

Design short-term, long-term, and graph-based memory architectures

Map tasks to specialist agents. Use when choosing which agent for a job, comparing agent capabilities, or routing to React/Next.js/Playwright/docs/code-quality experts. Keywords: which agent, best agent for this, delegate to expert, agent capability mapping.

Async/await patterns for FastAPI and SQLAlchemy. Use when working with async code, database sessions, concurrent operations, or debugging async issues in Python.

Extract and analyze mutational signatures from somatic variants using SigProfiler or MutationalPatterns to characterize mutagenic processes. Use when identifying DNA damage mechanisms or etiology in cancer genomes.

Expert capability for robust, stealthy, and efficient browser automation using Playwright Go.

Build scalable design systems with Tailwind CSS v4, design tokens, component libraries, and responsive patterns. Use when creating component libraries, implementing design systems, or standardizing UI patterns.