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Idiomatic Go 1.25+ development. Use when writing Go code, designing APIs, discussing Go patterns, or reviewing Go implementations. Emphasizes stdlib, concrete types, simple error handling, and minimal dependencies.

View, convert, and understand SAM/BAM/CRAM alignment files using samtools and pysam. Use when inspecting alignments, converting between formats, or understanding alignment file structure.

Find restriction enzyme cut sites in DNA sequences using Biopython Bio.Restriction. Search with single enzymes, batches of enzymes, or commercially available enzyme sets. Returns cut positions for linear or circular DNA. Use when finding restriction enzyme cut sites in sequences.

Analyzes time-to-event data using Kaplan-Meier curves, log-rank tests, and Cox proportional hazards regression with lifelines. Builds survival models from clinical and omics features. Use when predicting patient survival or modeling time-to-event outcomes.

Generate images with Flux 2 Klein (Black Forest Labs' distilled fast variant of Flux 2) on RunComfy — bundled with the model's documented prompting patterns so the skill gets sharper output than naive prompting against the same model. Documents Flux 2 Klein's strengths (sub-second latency, multi-reference brand styling, declarative subject-first prompts), the step-count strategy (4–8 for fast iter

Validate PCR primers for specificity, dimers, hairpins, and secondary structures using primer3-py thermodynamic calculations. Check self-complementarity, heterodimer formation, and 3' stability. Use when validating primer specificity and properties.

You are an error tracking and observability expert specializing in implementing comprehensive error monitoring solutions. Set up error tracking systems, configure alerts, implement structured logging,

Harmony batch correction for scRNA-seq and other omics. Removes batch effects from PCA embeddings while preserving biology. Run after PCA, before UMAP. Scales to millions of cells. Python (harmonypy, scanpy) and R (Seurat).

Padrão para interagir eficazmente com usuários para coletar informações ou obter decisões. Utilize quando precisar de entrada do usuário.

When the user wants to create, optimize, or structure a changelog or release notes page. Also use when the user mentions "changelog," "release notes," "what's new," "updates," "product updates," "version history," or "changelog.yourdomain.com." For sitewide page planning, use website-structure.

Discover RBP binding motifs from CLIP-seq peaks or single-nucleotide crosslink sites using HOMER, MEME/STREME, kpLogo, mCross (CL-position-registered motifs), PEKA (positional k-mer enrichment), RBPamp (affinity), and RNA Bind-n-Seq (RBNS) cross-validation. Use when characterizing RBP sequence specificity, registering motifs to crosslink positions, validating in vivo CLIP motifs against in vitro R

Use this skill when working with symbolic mathematics in Python. This skill should be used for symbolic computation tasks including solving equations algebraically, performing calculus operations (derivatives, integrals, limits), manipulating algebraic expressions, working with matrices symbolically, physics calculations, number theory problems, geometry computations, and generating executable cod