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Predicts 3D protein structures from amino acid sequences using ESMFold or AlphaFold3 (mock).

Python project organization, module architecture, and public API design. Use when setting up new projects, organizing modules, defining public interfaces with __all__, or planning directory layouts.

Gere vídeos de IA no RunComfy via CLI `runcomfy`, um roteador inteligente para um catálogo completo de modelos de vídeo como HappyHorse, Wan-AI Wan e ByteDance Seedance. Abrange geração de texto para vídeo (t2v) e imagem para vídeo (i2v).

Comprehensive toolkit for survival analysis and time-to-event modeling in Python using scikit-survival. Use this skill when working with censored survival data, performing time-to-event analysis, fitting Cox models, Random Survival Forests, Gradient Boosting models, or Survival SVMs, evaluating survival predictions with concordance index or Brier score, handling competing risks, or implementing an

Implement saga patterns for distributed transactions and cross-aggregate workflows. Use when coordinating multi-step business processes, handling compensating transactions, or managing long-running workflows.

Infer developmental trajectories and pseudotime from single-cell RNA-seq data using Monocle3, Slingshot, and scVelo for RNA velocity analysis. Use when inferring developmental trajectories or pseudotime.

When the user wants to design, optimize, or audit carousel/slider layouts for content display. Also use when the user mentions "carousel," "slider," "carousel layout," "testimonial carousel," "gallery carousel," "quote carousel," "image slider," or "carousel accessibility." For hero-area patterns, use hero-generator.

Manage Supabase projects, databases, migrations, Edge Functions, and storage using the `supabase` CLI.

Analyze MD trajectories from GROMACS, AMBER, NAMD, CHARMM, LAMMPS. Reads topology/trajectory into Universe objects; supports RMSD, RMSF, radius of gyration, contact maps, H-bonds, PCA, and custom distance/angle calculations. Use for post-simulation structural analysis; use OpenMM/GROMACS for running simulations.

Padrões ideais de criação de ViewModel e Wizard para Avalonia usando Zafiro e ReactiveUI.

RNA-seq specific quality control including rRNA contamination detection, strandedness verification, gene body coverage, and transcript integrity metrics. Use when validating RNA-seq libraries before differential expression analysis.

Write developer-oriented README as onboarding documentation. Use when creating/updating README, setting up new projects, or when new developers need to understand the codebase quickly. README = Entry point + Architecture overview + Working agreement.