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Analyzes pooled CRISPR screens with MAGeCK (Li et al 2014), covering count generation (mageck count), the RRA two-condition workflow (mageck test using alpha-RRA over per-sgRNA negative-binomial p-values), the MLE multi-condition workflow (mageck mle with explicit design matrix and beta-score output), normalization choice (median vs total vs control-sgRNA vs spike-in), sgRNA efficiency injection,

Comprehensive spreadsheet creation, editing, and analysis with support for formulas, formatting, data analysis, and visualization. When Claude needs to work with spreadsheets (.xlsx, .xlsm, .csv, .tsv, etc) for: (1) Creating new spreadsheets with formulas and formatting, (2) Reading or analyzing data, (3) Modify existing spreadsheets while preserving formulas, (4) Data analysis and visualization i

Expert in building voice AI applications - from real-time voice agents to voice-enabled apps. Covers OpenAI Realtime API, Vapi for voice agents, Deepgram for transcription, ElevenLabs for synthesis, LiveKit for real-time infrastructure, and WebRTC fundamentals. Knows how to build low-latency, production-ready voice experiences. Use when: voice ai, voice agent, speech to text, text to speech, realt

Orientação especializada para construir UIs Android modernas com Jetpack Compose, cobrindo gerenciamento de estado, navegação, desempenho e Material Design 3.

The Design System, Theme, and UX rules for the Physical AI Hub.

Molecular machine learning toolkit. Property prediction (ADMET, toxicity), GNNs (GCN, MPNN), MoleculeNet benchmarks, pretrained models, featurization, for drug discovery ML.

When the user wants to create or optimize an email sequence, drip campaign, automated email flow, or lifecycle email program. Also use when the user mentions "email sequence," "drip campaign," "nurture sequence," "onboarding emails," "welcome sequence," "re-engagement emails," "email automation," or "lifecycle emails." For in-app onboarding, see onboarding-cro.

React composition patterns that scale. Use when refactoring components with boolean prop proliferation, building flexible component libraries, or designing reusable APIs. Triggers on tasks involving compound components, render props, context providers, or component architecture. Includes React 19 API changes.

Gerencia o desenvolvimento de projetos Chronicle usando marcos rastreados em banco de dados, próximos passos e visualização de roteiro. Funciona com ferramentas MCP ou comandos CLI, eliminando atualizações manuais do DEVELOPMENT_HISTORY.md.

O SDK JavaScript/TypeScript do Azure Queue Storage (@azure/storage-queue) permite operações como enviar, receber, espiar e excluir mensagens em filas. Ele suporta recursos como tempo limite de visibilidade, codificação de mensagens e operações em lote.

Write clear, comprehensive technical documentation. Use when creating specs, architecture docs, runbooks, or API documentation. Handles technical specifications, system design docs, operational guides, and developer documentation with industry best practices.

Expert in secure mobile coding practices specializing in input