bg-szy

Query PubChem (110M+ compounds) directly via the PUG-REST/JSON API with plain `requests` — no SDK install required. Search by name/CID/SMILES/InChIKey/formula, retrieve properties (MW, XLogP, TPSA, H-bond counts), do similarity/substructure searches with async ListKey polling, fetch synonyms, descriptions, assay summaries, and download SDF/PNG. For local cheminformatics use rdkit; for bioactivity-

Scans the codebase to generate project-doc.md and AGENTS.md. Use when bootstrapping a new agent-driven repo, refreshing project documentation after architectural changes, or running a delta scan to detect drift. Runs a full scan on first use and a smart delta scan on subsequent runs. Uses understand-anything + context-mode when available, falls back to native tools otherwise. Only updates AGENTS.m

A conceptual skill for implementing CRUD features driven by Spec-Kit and Claude Code

SQL query optimization and database performance specialist. Use when

Use when doing ANY task involving Supabase. Triggers: Supabase products (Database, Auth, Edge Functions, Realtime, Storage, Vectors, Cron, Queues); client libraries and SSR integrations (supabase-js, @supabase/ssr) in Next.js, React, SvelteKit, Astro, Remix; auth issues (login, logout, sessions, JWT, cookies, getSession, getUser, getClaims, RLS); Supabase CLI or MCP server; schema changes, migrati

Infraestrutura em nuvem e fluxo de trabalho DevOps, abrangendo AWS, Azure, GCP, Kubernetes, Terraform, CI/CD, monitoramento e desenvolvimento nativo da nuvem.

Single-cell RNA-seq analysis. Load .h5ad/10X data, QC, normalization, PCA/UMAP/t-SNE, Leiden clustering, marker genes, cell type annotation, trajectory, for scRNA-seq analysis.

Queries PharmGKB / CPIC / DPWG for drug-gene interactions; calls CYP2D6/CYP2C9/CYP2C19/DPYD/TPMT/NUDT15/UGT1A1/SLCO1B1 star alleles and phenotype with PharmCAT, Cyrius (CYP2D6 structural variants), Aldy, Stargazer; applies Caudle 2020 activity-score translation. Use when implementing pharmacogenomic-guided prescribing, applying CPIC vs DPWG guidance, screening HLA risk alleles for ICI / antiepilep

Generate Mos Sparkle appcast.xml from the latest build zip and recent git changes (since a given commit), then sync to docs/ for publishing.

Identify error-prone APIs and dangerous configurations

O SDK do Azure Application Insights para .NET oferece monitoramento de desempenho de aplicativos e gerenciamento de recursos de observabilidade. Utilize-o para criar componentes do Application Insights, testes da web, pastas de trabalho, itens de análise e chaves de API.

Generate, edit, and restore images with Google's Nano Banana (Gemini image models). Use whenever the user asks to "generate an image", "create an icon/favicon/logo", "edit this photo", "restore an old photo", "make a pattern/texture/wallpaper", "draw a diagram/flowchart/architecture", or "tell a visual story" — even when they don't explicitly say Nano Banana or Gemini. Always prefer this skill ove