jackspace

This skill should be used when working with genomic interval data (BED files) for machine learning tasks. Use for training region embeddings (Region2Vec, BEDspace), single-cell ATAC-seq analysis (scEmbed), building consensus peaks (universes), or any ML-based analysis of genomic regions. Applies to BED file collections, scATAC-seq data, chromatin accessibility datasets, and region-based genomic fe

Validate, format, and work with JSON configuration files

Production-tested integration patterns for connecting React frontends to Cloudflare Worker backends with Hono, Clerk authentication, and D1 databases. Prevents common frontend-backend connection issues, CORS errors, auth token failures, and race conditions. Use when: connecting frontend to backend, implementing auth flow, setting up API calls, troubleshooting CORS, fixing race conditions, auth tok

Complete browser automation with Playwright. Auto-detects dev servers, writes clean test scripts to /tmp. Test pages, fill forms, take screenshots, check responsive design, validate UX, test login flows, check links, automate any browser task. Use when user wants to test websites, automate browser interactions, validate web functionality, or perform any browser-based testing.

Meta-skill for extracting and creating reusable Claude Code skills from past work sessions. Analyzes git history, code patterns, workflows, and documentation to identify harvestable skills, then generates comprehensive skill definitions with best practices, examples, and structured templates.

Use this skill when building MCP (Model Context Protocol) servers with TypeScript on Cloudflare Workers. This skill provides production-tested patterns for implementing tools, resources, and prompts using the official @modelcontextprotocol/sdk. It prevents 10+ common errors including export syntax issues, schema validation failures, memory leaks from unclosed transports, CORS misconfigurations, an

Machine learning in Python with scikit-learn. Use when working with supervised learning (classification, regression), unsupervised learning (clustering, dimensionality reduction), model evaluation, hyperparameter tuning, preprocessing, or building ML pipelines. Provides comprehensive reference documentation for algorithms, preprocessing techniques, pipelines, and best practices.

This skill should be used when working with annotated data matrices in Python, particularly for single-cell genomics analysis, managing experimental measurements with metadata, or handling large-scale biological datasets. Use when tasks involve AnnData objects, h5ad files, single-cell RNA-seq data, or integration with scanpy/scverse tools.

Autonomous biomedical AI agent framework for executing complex research tasks across genomics, drug discovery, molecular biology, and clinical analysis. Use this skill when conducting multi-step biomedical research including CRISPR screening design, single-cell RNA-seq analysis, ADMET prediction, GWAS interpretation, rare disease diagnosis, or lab protocol optimization. Leverages LLM reasoning wit

Complete guide for OpenAI's Assistants API v2: stateful conversational AI with built-in tools (Code Interpreter, File Search, Function Calling), vector stores for RAG (up to 10,000 files), thread/run lifecycle management, and streaming patterns. Both Node.js SDK and fetch approaches. ⚠️ DEPRECATION NOTICE: OpenAI plans to sunset Assistants API in H1 2026 in favor of Responses API. This skill remai

Automatically generates comprehensive test suites (unit, integration, E2E) based on code and past testing patterns. Use when user says "write tests", "test this", "add coverage", or after fixing bugs to create regression tests. Eliminates testing friction for ADHD users.

Fast DataFrame library (Apache Arrow). Select, filter, group_by, joins, lazy evaluation, CSV/Parquet I/O, expression API, for high-performance data analysis workflows.