Dados e Análise

Create, manipulate, and convert bedGraph files for genome browser visualization. Covers bedGraph format, conversion to/from bigWig, normalization, and signal processing. Use when handling coverage and signal tracks from ChIP-seq, ATAC-seq, or RNA-seq.

Comprehensive variant annotation using bcftools annotate/csq, VEP, SnpEff, and ANNOVAR. Add database annotations, predict functional consequences, and assess clinical significance with MANE transcript selection and pathogenicity scoring. Use when annotating variants with functional and clinical information.

Access real-time and historical stock market data, forex rates, cryptocurrency prices, commodities, economic indicators, and 50+ technical indicators via the Alpha Vantage API. Use when fetching stock prices (OHLCV), company fundamentals (income statement, balance sheet, cash flow), earnings, options data, market news/sentiment, insider transactions, GDP, CPI, treasury yields, gold/silver/oil pric

Infer cell-cell communication networks from scRNA-seq data using CellChat, NicheNet, and LIANA for ligand-receptor interaction analysis. Use when inferring ligand-receptor interactions between cell types.

Queries myvariant.info BioThings aggregator for ClinVar, gnomAD, dbSNP, dbNSFP, COSMIC, CADD, and CIViC annotations in batched, version-tracked requests. Use when annotating variant lists from multiple databases simultaneously without managing per-source APIs, and when reproducibility-grade analyses require recording source data versions via _meta.

Quantifies alternative splicing events (PSI/percent spliced in) from RNA-seq using SUPPA2 from transcript TPM or rMATS-turbo from BAM files. Calculates inclusion levels for skipped exons, alternative splice sites, mutually exclusive exons, and retained introns. Use when measuring splice site usage or isoform ratios from RNA-seq data.

O Azure Machine Learning SDK v2 para Python é usado para gerenciar workspaces de ML, trabalhos, modelos, conjuntos de dados, computação e pipelines.

Consulte proativamente o banco de dados do grafo de código para entender relacionamentos e o impacto das mudanças. Esta é sua ferramenta principal para compreender a estrutura do código, evitar mudanças que quebrem o sistema e obter contexto ao ler, pesquisar ou explorar a base de código.

Geospatial vector analysis extending pandas. Read/write spatial formats (Shapefile, GeoJSON, GeoPackage, Parquet, PostGIS), CRS handling, geometric ops (buffer, simplify, centroid, affine), spatial analysis (joins, overlays, dissolve, clipping, distance), visualization (choropleth, interactive maps, basemaps). Use for spatial joins, overlays, CRS transforms, area/distance, maps.

Chave API para as APIs de dados da MaxHub. Obtenha uma em https://www.aconfig.cn

A skill @delon/chart oferece componentes de gráficos empresariais G2Plot. É utilizada para o sistema de rastreamento de progresso de canteiros de obras da ng-events.

Environment and assets sub-skill for README-first AI repo reproduction. Use when the task is specifically to prepare a conservative conda-first environment, checkpoint and dataset path assumptions, cache location hints, and setup notes before any run on a README-documented repository. Do not use for repo scanning, full orchestration, paper interpretation, final run reporting, or generic environmen