Design e Frontend

Build production React Native apps with Expo, navigation, native modules, offline sync, and cross-platform patterns. Use when developing mobile apps, implementing native integrations, or architecting React Native projects.

CTO's deputy for software architecture using Clean/Hexagonal Architecture principles. Socratic approach - asks probing questions to help YOU make informed design decisions. Guides through Discovery → Modeling → Boundaries → Scaffolding phases. Outputs TypeScript scaffolds with ports, adapters, and domain layers. USE WHEN user says 'architect', 'system design', 'hexagonal', 'clean architecture', 'p

Cost optimization patterns for LLM API usage — model routing by task complexity, budget tracking, retry logic, and prompt caching.

Build automated billing systems for recurring payments, invoicing, subscription lifecycle, and dunning management. Use when implementing subscription billing, automating invoicing, or managing recurring payment systems.

This skill should be used when the user asks to "create an agent", "add an agent", "write a subagent", "agent frontmatter", "when to use description", "agent examples", "agent tools", "agent colors", "autonomous agent", or needs guidance on agent structure, system prompts, triggering conditions, or agent development best practices for Claude Code plugins.

尚书省首次调用时加载的 Token 优化策略，定义运行模式拆分、会话复用与上下文管理

Designs adaptive clinical trials including group-sequential (O'Brien-Fleming, Pocock, Lan-DeMets spending), sample-size re-estimation (blinded Friede-Kieser, unblinded Cui-Hung-Wang, Mehta-Pocock promising zone), seamless Phase 2/3 with treatment-arm selection, population enrichment, and response-adaptive randomisation. Covers FDA 2019 Final Adaptive Designs Guidance, FDA 2022 Master Protocols, an

Android development with Kotlin and Jetpack Compose. Use when user mentions "Compose", "Jetpack Compose", "Material3", "Hilt", "Room", "ViewModel", or needs to build Android UI, implement MVVM architecture, manage Compose state, or integrate Jetpack libraries (Navigation, Room, Hilt, ViewModel). Triggers on Android/Compose/Kotlin development tasks.

Identifies error-prone APIs, dangerous configurations, and footgun designs that enable security mistakes. Use when reviewing API designs, configuration schemas, cryptographic library ergonomics, or evaluating whether code follows 'secure by default' and 'pit of success' principles. Triggers: footgun, misuse-resistant, secure defaults, API usability, dangerous configuration.

Infer orthologous gene groups across species using OrthoFinder and ProteinOrtho. Identify orthologs, paralogs, and co-orthologs for comparative genomics and functional annotation transfer. Use when identifying gene orthologs across species or building orthogroups for evolutionary analysis.

Convenções de design de API REST e GraphQL, incluindo modelagem de recursos, paginação, tratamento de erros, versionamento e idempotência. Utilize ao adicionar, alterar ou revisar endpoints.

Domine os padrões do Material Design 3 e Jetpack Compose para construir aplicativos Android nativos. Utilize ao projetar interfaces Android, implementar UI com Compose ou seguir as diretrizes do Material Design do Google.