Explorar skills

End-to-end pooled and single-cell CRISPR screen analysis from FASTQ to hit genes. Orchestrates library design QC, guide counting, six-stage screen QC (plasmid Gini, replicate Pearson, CEGv2 PR-AUC, copy-number artifact), method-appropriate hit calling across MAGeCK RRA/MLE, BAGEL2, drugZ, JACKS, and Chronos, cancer-cell-line copy-number correction (CRISPRcleanR / Chronos), batch correction for mul

Optimize vector index performance for latency, recall, and memory. Use when tuning HNSW parameters, selecting quantization strategies, or scaling vector search infrastructure.

Usado quando o usuário deseja que seu pet Claude Code cante uma música. É ativado por solicitações que combinam o conceito de seu companheiro Claude Code com canto ou música, suportando gatilhos multilíngues.

When the user wants to get press coverage, appear on podcasts, or build relationships with journalists and content creators. Also use when the user mentions "podcast guesting", "press outreach", "PR", "media exposure", "get on podcasts", or "journalist outreach".

Padrões modernos de autenticação e segurança para aplicações web, com expertise em tokens JWT, fluxos OAuth2, gerenciamento de sessão, RBAC, MFA, segurança de API e arquiteturas zero-trust. Estes padrões agnósticos de framework funcionam com qualquer stack de tecnologia.

End-to-end metagenomics workflow from FASTQ to taxonomic and functional profiles. Covers Kraken2 classification, Bracken abundance estimation, and HUMAnN functional profiling. Use when profiling metagenomic samples.

Assesses RNA-seq data quality specifically for alternative splicing analysis. QC layers include experimental design audit (library prep, read length, depth, replicates), STAR 2-pass cohort-style alignment, junction saturation curves and discovery plateau detection, novel-vs-known junction ratio diagnostics, junction-overhang distribution, splice-site strength scoring (MaxEntScan intrinsic + Splice

Spring Boot architecture patterns, REST API design, layered services, data access, caching, async processing, and logging. Use for Java Spring Boot backend work.

Database migration best practices for schema changes, data migrations, rollbacks, and zero-downtime deployments across PostgreSQL, MySQL, and common ORMs (Prisma, Drizzle, Django, TypeORM, golang-migrate).

Execute Hugging Face Hub operations using the `hf` CLI. Use when the user needs to download models/datasets/spaces, upload files to Hub repositories, create repos, manage local cache, or run compute jobs on HF infrastructure. Covers authentication, file transfers, repository creation, cache operations, and cloud compute.

Read/write SAM/BAM/CRAM, VCF/BCF, FASTA/FASTQ. Region queries, pileup, variant filtering, read groups. Python htslib wrapper exposing samtools/bcftools CLI. Use STAR/BWA for alignment; GATK/DeepVariant for variant calling.

Advanced swarm orchestration patterns for research, development, testing, and complex distributed workflows