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Guide for implementing smooth, native-feeling animations using React's View Transition API (`<ViewTransition>` component, `addTransitionType`, and CSS view transition pseudo-elements). Use this skill whenever the user wants to add page transitions, animate route changes, create shared element animations, animate enter/exit of components, animate list reorder, implement directional (forward/back) n

Estimate causal effects between exposures and outcomes using genetic variants as instrumental variables with TwoSampleMR. Implements IVW, MR-Egger, weighted median, and MR-PRESSO methods for robust causal inference from GWAS summary statistics. Use when testing whether an exposure causally affects an outcome using genetic instruments.

Guidelines for upgrading Expo SDK versions and fixing dependency issues

Ensembl REST API for gene/transcript/variant annotations in 300+ species. Gene info by symbol/ID, sequence, cross-refs (HGNC, RefSeq, UniProt), regulatory features. For bulk local use pyensembl; for pathways use kegg-database.

JUnit 5 testing patterns and parameterized-test guidance. Use when writing or reviewing Java unit tests.

API contract testing with Portman by Apideck. Use when generating Postman collections from OpenAPI specs, writing contract tests, variation tests, integration tests, fuzz testing, or setting up CI/CD API test pipelines. Portman converts OpenAPI 3.x specs into Postman collections with auto-generated test suites.

Python framework for single- and multi-objective optimization with evolutionary algorithms. Define vectorized objectives and constraints; solve with NSGA-II, NSGA-III, MOEA/D, GAs, or differential evolution. Analyze Pareto fronts, visualize trade-offs, customize operators and callbacks. For engineering design, hyperparameter search, and conflicting objectives. Alternatives: scipy.optimize (single-

Fuzzing dictionaries guide fuzzers with domain-specific tokens. Use when fuzzing parsers, protocols, or format-specific code.

Padrão de escrita de testes de backend da Allra. Use ao escrever código de teste, escolher auxiliares de teste, gerar dados de teste com Fixture Monkey ou verificar a cobertura de teste.

Production-ready patterns and best practices for MCP servers - architecture, security, performance, and maintenance

Corrects the gene-independent copy-number artifact in CRISPR-Cas9 screens (Aguirre 2016 / Munoz 2016 Cancer Discov) where amplified loci appear essential from DNA-damage burden of simultaneous cuts. Covers the p53-dependent G2-arrest mechanism, CRISPRcleanR (Iorio 2018) unsupervised pre-hoc correction, CERES (Meyers 2017) joint CN + gene-effect model, Chronos (Dempster 2021) DepMap-standard popula

De novo genome assembly from Oxford Nanopore or PacBio long reads using Flye and Canu. Produces highly contiguous assemblies suitable for complete bacterial genomes and resolving complex regions. Use when assembling genomes from ONT or PacBio reads.