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Detect allele-specific chromatin accessibility from ATAC-seq using WASP, GATK ASEReadCounter, or RASQUAL. Use when mapping cis-regulatory genetic variants from heterozygous SNPs, separating cis from trans regulation, building chromatin QTL (caQTL) maps, validating GWAS variant function with allelic imbalance, or detecting reference allele mapping bias before downstream analysis.

Systematic code maturity assessment using Trail of Bits' 9-category framework. Analyzes codebase for arithmetic safety, auditing practices, access controls, complexity, decentralization, documentation, MEV risks, low-level code, and testing. Produces professional scorecard with evidence-based ratings and actionable recommendations.

Use para projetar endpoints de API RESTful em projetos FastAPI ou Python, cobrindo a criação de endpoints GET/POST/PUT/DELETE, validação de requisições com Pydantic, formatação de respostas JSON, seleção de códigos de status, paginação, filtragem e ordenação. Não é para APIs GraphQL, manipuladores WebSocket ou endpoints não-RESTful.

Sistema de geração de apresentações PowerPoint de nível empresarial, utilizando técnicas de prompting baseadas em evidências e design baseado em restrições. É ideal para criar apresentações profissionais que exigem qualidade visual consistente, conformidade com acessibilidade e integração de dados complexos, implementando um fluxo de trabalho html2pptx.

Develop AI-powered applications using Genkit in Node.js/TypeScript. Use when the user asks about Genkit, AI agents, flows, or tools in JavaScript/TypeScript, or when encountering Genkit errors, validation issues, type errors, or API problems.

Analyze genome collinearity and syntenic blocks using MCScanX, SyRI, and JCVI for comparative genomics. Detect conserved gene order, chromosomal rearrangements, and whole-genome duplications. Use when comparing genome structure between species or identifying conserved genomic regions.

Video outpainting on RunComfy via the `runcomfy` CLI — extend the spatial canvas of a video, change aspect ratio (9:16 vertical to 16:9 horizontal or vice versa), add environment beyond the original frame while preserving the central action. Routes prompt-shaped spatial extension through Wan 2-7 edit-video and points the agent at dedicated ComfyUI outpaint workflows when seam quality matters for h

The market analysis function of Gate Exchange — liquidity, momentum, liquidation, funding arbitrage, basis, manipulation risk, order book explainer, slippage simulation. Use when the user asks about liquidity, depth, slippage, buy/sell pressure, liquidation, funding rate arbitrage, basis/premium, manipulation risk, order book explanation, or slippage simulation (e.g. market buy $X slippage). Trigg

Debugging specialist for errors, test failures, and unexpected

When the user wants to choose or optimize rendering strategy for SEO. Also use when the user mentions "SSR," "SSG," "CSR," "ISR," "static rendering," "dynamic rendering," "server-side rendering," "client-side rendering," "JavaScript rendering," "pre-rendering," "prerender," "content in initial HTML," or "crawler visibility." For crawl issues, use site-crawlability.

This skill should be used when the user wants to "create a skill", "add a skill to plugin", "write a new skill", "improve skill description", "organize skill content", or needs guidance on skill structure, progressive disclosure, or skill development best practices for Claude Code plugins.

Counts RNA-seq reads overlapping GTF gene features. Takes sorted STAR BAMs plus GTF; outputs a per-gene tab-delimited matrix across samples. Handles strandedness (0/1/2), paired-end, multi-sample batch counting in one command, and outputs assignment statistics. Use Salmon for alignment-free quantification; use featureCounts when STAR BAMs already exist.