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"Solubility-optimized protein sequence design using SolubleMPNN. Use this skill when: (1) Designing for E. coli expression, (2) Optimizing solubility of designed proteins, (3) Reducing aggregation propensity, (4) Need high-yield expression, (5) Avoiding inclusion body formation.

When the user wants to plan a product launch, execute launch channels, or create a launch checklist. Also use when the user mentions "product launch," "launch strategy," "product announcement," "launch channels," or "market launch." For GTM motion and positioning, use gtm-strategy. For cold start and first users, use cold-start-strategy. For Product Hunt day-of, use product-hunt-launch.

When the user wants to add or optimize structured data (Schema.org, JSON-LD). Also use when the user mentions "schema," "structured data," "JSON-LD," "rich results," "rich snippets," "Google rich snippets," "featured snippet schema," "add schema to page," "missing structured data," "schema validation error," "Schema Markup Validator," "Google Rich Results Test," "FAQ schema," "Article schema," "Or

Applies multiple testing correction methods including FDR, Bonferroni, and q-value for genomics data. Use when filtering differential expression results, setting significance thresholds, or choosing between correction methods for different study designs.

Queries Polymarket market data and CLOB state, and manages CLOB orders via the Grimoire venue CLI wrapper backed by the official Polymarket CLI.

Docker and Docker Compose patterns for local development, container security, networking, volume strategies, and multi-service orchestration.

Integrate multiple scRNA-seq samples/batches using Harmony, scVI, Seurat anchors, and fastMNN. Remove technical variation while preserving biological differences. Use when integrating multiple scRNA-seq batches or datasets.

Quality control, filtering, normalization, and feature selection for spatial transcriptomics data. Calculate QC metrics, filter spots/cells, normalize counts, and identify highly variable genes. Use when filtering and normalizing spatial transcriptomics data.

Work with FASTQ quality scores using Biopython. Use when analyzing read quality, filtering by quality, trimming low-quality bases, or generating quality reports.

Interact with ClawDirect, a directory of social web experiences for AI agents. Use this skill to browse the directory, like entries, or add new sites. Requires ATXP authentication for MCP tool calls. Triggers: browsing agent-oriented websites, discovering social platforms for agents, liking/voting on directory entries, or submitting new agent-facing sites to ClawDirect.

Guide for creating comprehensive PR descriptions with proper structure, diagrams, and documentation for code reviews.

Analisa, transforma e processa arquivos CSV com recursos avançados de manipulação de dados.