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Generates rich technical documentation pages with dark-mode Mermaid diagrams, source code citations, and first-principles depth. Use when writing documentation, generating wiki pages, creating technical deep-dives, or documenting specific components or systems.

Implements Manus-style file-based planning for complex tasks. Creates task_plan.md, findings.md, and progress.md. Use when starting complex multi-step tasks, research projects, or any task requiring >5 tool calls.

Next.js 16 Cache Components - PPR, use cache directive, cacheLife, cacheTag, updateTag

Query CELLxGENE Census (61M+ cells). Search by cell type/tissue/disease/organism; get AnnData, stream out-of-core, train PyTorch models. For your own data use scanpy; for annotated data use anndata.

Detects somatic mutations in circulating tumor DNA using variant callers optimized for low allele fractions with UMI-based error suppression. Reliably detects mutations at VAF above 0.5 percent using consensus-based approaches. Use when identifying tumor mutations from plasma DNA or tracking specific variants.

Normalizes and transforms RNA-seq count matrices for DE, visualization, clustering, and ML. Covers between-sample (TMM, TMMwsp, RLE/median-of-ratios, upper quartile), within-sample (TPM, FPKM/RPKM), variance-stabilizing (VST, rlog, log-CPM), GC-content correction (cqn, EDASeq), and single-cell (scran deconvolution, scanpy normalize_total). Encodes the composition-bias rationale, the "most genes no

Marker gene-based taxonomic profiling using MetaPhlAn 4. Provides accurate species-level relative abundances using clade-specific markers. Use when accurate taxonomic profiling is needed and computational resources are limited, or for comparison with HMP/other MetaPhlAn studies.

AI-powered data analysis for Empathy Ledger. Use when working with themes, quotes, story suggestions, transcript analysis, storyteller connections, or any feature requiring extracted insights. Ensures consistent analysis patterns across the platform.

Create restriction maps showing enzyme cut positions on DNA sequences using Biopython Bio.Restriction. Visualize cut sites, calculate distances between sites, and generate text or graphical maps. Use when creating or analyzing restriction maps.

Sets up new projects and generates workflow files like CLAUDE.md, AGENTS.md, Plans.md. Use when user mentions セットアップ, setup, 初期化, initialize, 新規プロジェクト, ワークフローファイル生成. Do NOT load for: 実装作業, レビュー, ビルド検証, デプロイ.

Guia para práticas e frameworks de teste.

Construa sistemas de faturamento automatizados para pagamentos recorrentes, emissão de faturas, ciclo de vida de assinaturas e gestão de cobrança. Utilize ao implementar faturamento por assinatura, automatizar a emissão de faturas ou gerenciar sistemas de pagamento recorrente.