bg-szy

Trim PCR primers from aligned reads in amplicon-panel BAMs using samtools ampliconclip. Use when processing SARS-CoV-2 ARTIC, hereditary cancer panels, ctDNA hot-spot panels, or any amplicon assay where primer-derived bases would falsely confirm reference at primer footprints.

Query Open Targets Platform for target-disease associations, drug target discovery, tractability/safety data, genetics/omics evidence, known drugs, for therapeutic target identification.

Multi-modal single-cell analysis with muon/MuData. Joint RNA+ATAC (10x Multiome), CITE-seq (RNA+protein), other multi-omics. MuData holds per-modality AnnData with shared obs. WNN joint embedding, per-modality preprocessing, MOFA factor analysis. Use scanpy-scrna-seq for single-modality RNA; use muon when combining 2+ omics from the same cells.

Remove batch effects from RNA-seq data using ComBat, ComBat-Seq, limma removeBatchEffect, and SVA for unknown batch variables. Use when correcting batch effects in expression data.

Toolkit for interacting with and testing local web applications using Playwright. Supports verifying frontend functionality, debugging UI behavior, capturing browser screenshots, and viewing browser logs.

生成紧急情况下快速访问的医疗信息摘要卡片。当用户需要旅行、就诊准备、紧急情况或询问"紧急信息"、"医疗卡片"、"急救信息"时使用此技能。提取关键信息（过敏、用药、急症、植入物），支持多格式输出（JSON、文本、二维码），用于急救或快速就医。

分析心理健康数据、识别心理模式、评估心理健康状况、提供个性化心理健康建议。支持与睡眠、运动、营养等其他健康数据的关联分析。

Cria novas skills do Claude Code seguindo as melhores práticas, orientando sobre estrutura, nomenclatura, descrições e divulgação progressiva. Use ao criar uma skill, construir uma capacidade ou perguntar sobre as melhores práticas.

When the user wants to plan or execute a rebrand—domain change, 301 redirects, migration, or announcement. Also use when the user mentions "rebranding," "rebrand," "domain change," "domain migration," "301 redirect," "change domain name," "rebrand announcement," "social media rebrand," "brand launch," or "domain redirect." For domain choice, use domain-selection.

Acesse e analise informações abrangentes sobre medicamentos do banco de dados DrugBank, incluindo propriedades, interações, alvos, vias, estruturas químicas e dados farmacológicos. Esta skill é ideal para dados farmacêuticos, pesquisa de descoberta de medicamentos, estudos de farmacologia e análise de interações.

Posts a progress checkpoint to the currently active GitHub Issue thread. Saves work state including completed tasks, in-progress items, files changed, commits, and blockers without changing workflow phases. Requires an already-claimed in-progress thread. Use when user wants to save progress, record milestones, document blockers, or preserve state before ending a session.

No-code automation democratizes workflow building. Zapier and Make (formerly Integromat) let non-developers automate business processes without writing code. But no-code doesn't mean no-complexity - these platforms have their own patterns, pitfalls, and breaking points. This skill covers when to use which platform, how to build reliable automations, and when to graduate to code-based solutions. K